3D7O

Human hemoglobin, nitrogen dioxide anion modified

3D7O の概要

• エントリーDOI: 10.2210/pdb3d7o/pdb
• 分子名称: Hemoglobin subunit alpha, Hemoglobin subunit beta, NITRITE ION, ... (6 entities in total)
• 機能のキーワード: human hemoglobin, acetylation, disease mutation, glycation, glycoprotein, heme, iron, metal-binding, oxygen transport, polymorphism, transport, hypotensive agent, pyruvate, s-nitrosylation, vasoactive
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32457.67

構造登録者

Yi, J.,Safo, M.K.,Richter-Addo, G.B. (登録日: 2008-05-21, 公開日: 2009-05-05, 最終更新日: 2023-08-30)

主引用文献

Yi, J.,Safo, M.K.,Richter-Addo, G.B.
The nitrite anion binds to human hemoglobin via the uncommon O-nitrito mode.
Biochemistry, 47:8247-8249, 2008

PubMed Abstract: The nitrite anion is known to oxidize and degrade hemoglobin (Hb). Recent literature reports suggest a nitrite reductase activity for Hb, converting nitrite into nitric oxide. Surprisingly, no structural information about Hb-nitrite interactions has been reported. We have determined the crystal structure of the ferric Hb-nitrite complex at 1.80 A resolution. The nitrite ligand adopts the uncommon O-nitrito binding mode. In addition, the nitrito conformations in the alpha and beta subunits are different, reflecting subtle effects of the distal His in orienting the nitrite ligand in the O-nitrito binding mode.

PubMed: 18630930
DOI: 10.1021/bi801015c

実験手法

X-RAY DIFFRACTION (1.8 Å)