3D7J

SCO6650, a 6-pyruvoyltetrahydropterin synthase homolog from Streptomyces coelicolor

Summary for 3D7J

• Entry DOI: 10.2210/pdb3d7j/pdb
• Descriptor: Uncharacterized protein SCO6650, SODIUM ION, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: t-fold, unknown function
• Biological source: Streptomyces coelicolor
• Total number of polymer chains: 6
• Total formula weight: 100258.47

Authors

Spoonamore, J.E.,Roberts, S.A.,Heroux, A.,Bandarian, V. (deposition date: 2008-05-21, release date: 2008-10-21, Last modification date: 2024-10-30)

Primary citation

Spoonamore, J.E.,Roberts, S.A.,Heroux, A.,Bandarian, V.
Structure of a 6-pyruvoyltetrahydropterin synthase homolog from Streptomyces coelicolor.
Acta Crystallogr.,Sect.F, 64:875-879, 2008

PubMed Abstract: The X-ray crystal structure of the 6-pyruvoyltetrahydropterin synthase (PTPS) homolog from Streptomyces coelicolor, SCO 6650, was solved at 1.5 A resolution. SCO 6650 forms a hexameric T-fold that closely resembles other PTPS proteins. The biological activity of SCO 6650 is unknown, but it lacks both a required active-site zinc metal ion and the essential catalytic triad and does not catalyze the PTPS reaction. However, SCO 6650 maintains active-site residues consistent with binding a pterin-like substrate.

PubMed: 18931427
DOI: 10.1107/S1744309108027048

Experimental method

X-RAY DIFFRACTION (1.45 Å)