3D6R

Structure of an avian influenza A virus NS1 protein effector domain

3D6R の概要

• エントリーDOI: 10.2210/pdb3d6r/pdb
• 分子名称: Non-structural protein 1 (2 entities in total)
• 機能のキーワード: influenza, ns1, effector domain, alternative splicing, cytoplasm, host-virus interaction, interferon antiviral system evasion, nucleus, rna-binding, suppressor of rna silencing, viral protein
• 由来する生物種: Influenza A virus
• 細胞内の位置: Host nucleus: P69270
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 35508.70

構造登録者

Hale, B.G.,Barclay, W.S.,Randall, R.E.,Russell, R.J. (登録日: 2008-05-20, 公開日: 2008-08-12, 最終更新日: 2024-02-21)

主引用文献

Hale, B.G.,Barclay, W.S.,Randall, R.E.,Russell, R.J.
Structure of an avian influenza A virus NS1 protein effector domain.
Virology, 378:1-5, 2008

PubMed Abstract: Influenza A virus NS1 protein is a multifunctional virulence factor. Here, we report a crystal structure for the NS1 effector domain of avian influenza virus A/Duck/Albany/76. Comparison of this structure with that reported for a human strain shows both proteins share a common monomer conformation, albeit with subtle differences. Strikingly, our data reveal a novel helix-helix dimeric interface between monomers of the avian NS1 protein, which is also found in the human NS1 crystal lattice. We re-evaluate the current model of NS1 dimeric assembly, and provide biochemical evidence to show tryptophan-187 (a residue located at the helix-helix interface) is essential for dimerization of this effector domain.

PubMed: 18585749
DOI: 10.1016/j.virol.2008.05.026

実験手法

X-RAY DIFFRACTION (1.997 Å)