3D62
Development of Broad-Spectrum Halomethyl Ketone Inhibitors Against Coronavirus Main Protease 3CLpro
Summary for 3D62
Entry DOI | 10.2210/pdb3d62/pdb |
Descriptor | 3C-like proteinase, benzyl (2-oxopropyl)carbamate (3 entities in total) |
Functional Keywords | main protease 3clpro, sars, inhibitor, 95990, atp-binding, endonuclease, exonuclease, helicase, hydrolase, membrane, metal-binding, nuclease, nucleotide-binding, nucleotidyltransferase, rna replication, rna-binding, rna-directed rna polymerase, thiol protease, transferase, transmembrane, zinc-finger |
Biological source | SARS coronavirus |
Total number of polymer chains | 1 |
Total formula weight | 33407.15 |
Authors | Bacha, U.,Barrila, J.,Gabelli, S.B.,Kiso, Y.,Amzel, L.M.,Freire, E. (deposition date: 2008-05-18, release date: 2008-07-01, Last modification date: 2017-10-25) |
Primary citation | Bacha, U.,Barrila, J.,Gabelli, S.B.,Kiso, Y.,Mario Amzel, L.,Freire, E. Development of broad-spectrum halomethyl ketone inhibitors against coronavirus main protease 3CL(pro). Chem.Biol.Drug Des., 72:34-49, 2008 Cited by PubMed: 18611220DOI: 10.1111/j.1747-0285.2008.00679.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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