3D62

Development of Broad-Spectrum Halomethyl Ketone Inhibitors Against Coronavirus Main Protease 3CLpro

3D62 の概要

• エントリーDOI: 10.2210/pdb3d62/pdb
• 分子名称: 3C-like proteinase, benzyl (2-oxopropyl)carbamate (3 entities in total)
• 機能のキーワード: main protease 3clpro, sars, inhibitor, 95990, atp-binding, endonuclease, exonuclease, helicase, hydrolase, membrane, metal-binding, nuclease, nucleotide-binding, nucleotidyltransferase, rna replication, rna-binding, rna-directed rna polymerase, thiol protease, transferase, transmembrane, zinc-finger
• 由来する生物種: SARS coronavirus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33407.15

構造登録者

Bacha, U.,Barrila, J.,Gabelli, S.B.,Kiso, Y.,Amzel, L.M.,Freire, E. (登録日: 2008-05-18, 公開日: 2008-07-01, 最終更新日: 2017-10-25)

• 主引用文献: Bacha, U.,Barrila, J.,Gabelli, S.B.,Kiso, Y.,Mario Amzel, L.,Freire, E.; Development of broad-spectrum halomethyl ketone inhibitors against coronavirus main protease 3CL(pro).; Chem.Biol.Drug Des., 72:34-49, 2008; PubMed: 18611220; DOI: 10.1111/j.1747-0285.2008.00679.x

実験手法

X-RAY DIFFRACTION (2.7 Å)