3D3E

Crystal Structure of Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) in Complex with Benzamide Inhibitor

3D3E の概要

• エントリーDOI: 10.2210/pdb3d3e/pdb
• 関連するPDBエントリー: 3CZR
• 分子名称: Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-cyclopropyl-N-(trans-4-pyridin-3-ylcyclohexyl)-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, 11beta, hydroxysteroid, dehydrogenase, endoplasmic reticulum, glycoprotein, lipid metabolism, membrane, microsome, nadp, polymorphism, signal-anchor, steroid metabolism, transmembrane
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Endoplasmic reticulum membrane; Single-pass type II membrane protein: P28845
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 132051.04

構造登録者

Wang, Z.,Sudom, A.,Liu, J.,Walker, N.P. (登録日: 2008-05-09, 公開日: 2008-07-01, 最終更新日: 2023-08-30)

• 主引用文献: Julian, L.D.,Wang, Z.,Bostick, T.,Caille, S.,Choi, R.,Degraffenreid, M.,Di, Y.,He, X.,Hungate, R.W.,Jaen, J.C.,Liu, J.,Monshouwer, M.,McMinn, D.,Rew, Y.,Sudom, A.,Sun, D.,Tu, H.,Ursu, S.,Walker, N.,Yan, X.,Ye, Q.,Powers, J.P.; Discovery of Novel, Potent Benzamide Inhibitors of 11beta-Hydroxysteroid Dehydrogenase Type 1 (11beta-HSD1) Exhibiting Oral Activity in an Enzyme Inhibition ex Vivo Model; J.Med.Chem., 51:3953-3960, 2008; PubMed: 18553955; DOI: 10.1021/jm800310g

実験手法

X-RAY DIFFRACTION (2.6 Å)