3D28
Crystal structure of hcv ns5b polymerase with a novel benzisothiazole inhibitor
3D28 の概要
エントリーDOI | 10.2210/pdb3d28/pdb |
関連するPDBエントリー | 3BR9 3BSA 3BSC 3CDE 3CO9 3CVK 3CWJ |
分子名称 | RNA-directed RNA polymerase, (5S)-1-benzyl-3-(1,1-dioxido-1,2-benzisothiazol-3-yl)-4-hydroxy-5-(1-methylethyl)-1,5-dihydro-2H-pyrrol-2-one (3 entities in total) |
機能のキーワード | protein-ligand complex, rna-directed rna polymerase, nucleotidyltransferase, nucleotide-binding, transcription, hydrolase, transferase |
由来する生物種 | Hepatitis C virus (isolate BK) (HCV) |
細胞内の位置 | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26663 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 129484.40 |
構造登録者 | Han, Q.,Showalter, R.E.,Zhao, Q.,Kissinger, C.R. (登録日: 2008-05-07, 公開日: 2009-05-19, 最終更新日: 2024-04-03) |
主引用文献 | Kim, S.H.,Tran, M.T.,Ruebsam, F.,Xiang, A.X.,Ayida, B.,McGuire, H.,Ellis, D.,Blazel, J.,Tran, C.V.,Murphy, D.E.,Webber, S.E.,Zhou, Y.,Shah, A.M.,Tsan, M.,Showalter, R.E.,Patel, R.,Gobbi, A.,LeBrun, L.A.,Bartkowski, D.M.,Nolan, T.G.,Norris, D.A.,Sergeeva, M.V.,Kirkovsky, L.,Zhao, Q.,Han, Q.,Kissinger, C.R. Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase. Bioorg.Med.Chem.Lett., 18:4181-4185, 2008 Cited by PubMed: 18554907DOI: 10.1016/j.bmcl.2008.05.083 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.3 Å) |
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