3D25

Crystal structure of HA-1 minor histocompatibility antigen bound to human class I MHC HLA-A2

3D25 の概要

• エントリーDOI: 10.2210/pdb3d25/pdb
• 分子名称: HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Nonameric peptide from HA-1, ... (4 entities in total)
• 機能のキーワード: mhc, hla-a2, secondary anchor residue, glycoprotein, immune system, minor histocompatibility antigen, stem cell transplantation, immune response
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P01892; Secreted: P61769
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 44385.22

構造登録者

Nicholls, S.,Piper, K.P.,Mohammed, F.,Dafforn, T.R.,Tenzer, S.,Salim, M.,Mahendra, P.,Craddock, C.,van Endert, P.,Schild, H.,Cobbold, M.,Engelhard, V.H.,Moss, P.A.H.,Willcox, B.E. (登録日: 2008-05-07, 公開日: 2009-02-10, 最終更新日: 2023-08-30)

• 主引用文献: Nicholls, S.,Piper, K.P.,Mohammed, F.,Dafforn, T.R.,Tenzer, S.,Salim, M.,Mahendra, P.,Craddock, C.,van Endert, P.,Schild, H.,Cobbold, M.,Engelhard, V.H.,Moss, P.A.,Willcox, B.E.; Secondary anchor polymorphism in the HA-1 minor histocompatibility antigen critically affects MHC stability and TCR recognition; Proc.Natl.Acad.Sci.USA, 106:3889-3894, 2009; PubMed: 19234124; DOI: 10.1073/pnas.0900411106

実験手法

X-RAY DIFFRACTION (1.3 Å)