3D23

Main protease of HCoV-HKU1

Summary for 3D23

• Entry DOI: 10.2210/pdb3d23/pdb
• Related PRD ID: PRD_002214
• Descriptor: 3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE (3 entities in total)
• Functional Keywords: main protease, atp-binding, endonuclease, exonuclease, helicase, membrane, metal-binding, nuclease, nucleotide-binding, nucleotidyltransferase, protease, rna replication, rna-binding, rna-directed rna polymerase, thiol protease, transferase, transmembrane, zinc-finger, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human coronavirus (HCoV-HKU1); More
• Total number of polymer chains: 8
• Total formula weight: 134761.93

Authors

Zhao, Q.,Chen, C.,Li, S.,Zou, Y. (deposition date: 2008-05-07, release date: 2008-09-16, Last modification date: 2023-11-15)

• Primary citation: Zhao, Q.,Li, S.,Xue, F.,Zou, Y.,Chen, C.,Bartlam, M.,Rao, Z.; Structure of the main protease from a global infectious human coronavirus, HCoV-HKU1.; J.Virol., 82:8647-8655, 2008; PubMed: 18562531; DOI: 10.1128/JVI.00298-08

Experimental method

X-RAY DIFFRACTION (2.5 Å)