3D23

Main protease of HCoV-HKU1

3D23 の概要

• エントリーDOI: 10.2210/pdb3d23/pdb
• 関連するBIRD辞書のPRD_ID: PRD_002214
• 分子名称: 3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE (3 entities in total)
• 機能のキーワード: main protease, atp-binding, endonuclease, exonuclease, helicase, membrane, metal-binding, nuclease, nucleotide-binding, nucleotidyltransferase, protease, rna replication, rna-binding, rna-directed rna polymerase, thiol protease, transferase, transmembrane, zinc-finger, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human coronavirus (HCoV-HKU1); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 134761.93

構造登録者

Zhao, Q.,Chen, C.,Li, S.,Zou, Y. (登録日: 2008-05-07, 公開日: 2008-09-16, 最終更新日: 2023-11-15)

• 主引用文献: Zhao, Q.,Li, S.,Xue, F.,Zou, Y.,Chen, C.,Bartlam, M.,Rao, Z.; Structure of the main protease from a global infectious human coronavirus, HCoV-HKU1.; J.Virol., 82:8647-8655, 2008; PubMed: 18562531; DOI: 10.1128/JVI.00298-08

実験手法

X-RAY DIFFRACTION (2.5 Å)