3CWF

Crystal structure of PAS domain of two-component sensor histidine kinase

3CWF の概要

• エントリーDOI: 10.2210/pdb3cwf/pdb
• 分子名称: Alkaline phosphatase synthesis sensor protein phoR, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: bacillus subtilis, pas domain, alkaline phosphatase synthesis sensor protein phor, structural genomics, psi-2, protein structure initiative, midwest center for structural genomics, mcsg, kinase, membrane, phosphate transport, phosphoprotein, transferase, transmembrane, transport, two-component regulatory system
• 由来する生物種: Bacillus subtilis subsp. subtilis
• 細胞内の位置: Cell membrane; Multi-pass membrane protein (Probable): P23545
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 26442.92

構造登録者

Chang, C.,Tesar, C.,Gu, M.,Joachimiak, A.,Midwest Center for Structural Genomics (MCSG) (登録日: 2008-04-21, 公開日: 2008-05-06, 最終更新日: 2024-02-21)

主引用文献

Chang, C.,Tesar, C.,Gu, M.,Babnigg, G.,Joachimiak, A.,Pokkuluri, P.R.,Szurmant, H.,Schiffer, M.
Extracytoplasmic PAS-like domains are common in signal transduction proteins.
J.Bacteriol., 192:1156-1159, 2010

PubMed Abstract: We present the crystal structure of the extracytoplasmic domain of the Bacillus subtilis PhoR sensor histidine kinase, part of a two-component system involved in adaptation to low environmental phosphate concentrations. In addition to the PhoR structure, we predict that the majority of the extracytoplasmic domains of B. subtilis sensor kinases will adopt a fold similar to the ubiquitous PAS domain.

PubMed: 20008068
DOI: 10.1128/JB.01508-09

実験手法

X-RAY DIFFRACTION (2.2 Å)