3CSS

Crystal structure of 6-phosphogluconolactonase from Leishmania guyanensis

3CSS の概要

• エントリーDOI: 10.2210/pdb3css/pdb
• 関連するPDBエントリー: 3CH7
• 分子名称: 6-phosphogluconolactonase, PHOSPHATE ION (3 entities in total)
• 機能のキーワード: structural genomics, medical structural genomics of pathogenic protozoa consortium, sgpp, 6-phosphogluconolactonase, leishmaniasis, hydrolase, psi-2, protein structure initiative
• 由来する生物種: Leishmania braziliensis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28783.76

構造登録者

Arakaki, T.L.,Merritt, E.A.,Structural Genomics of Pathogenic Protozoa Consortium (SGPP) (登録日: 2008-04-10, 公開日: 2008-04-22, 最終更新日: 2023-08-30)

主引用文献

Painter, J.,Merritt, E.A.
Optimal description of a protein structure in terms of multiple groups undergoing TLS motion.
Acta Crystallogr.,Sect.D, 62:439-450, 2006

PubMed Abstract: A single protein crystal structure contains information about dynamic properties of the protein as well as providing a static view of one three-dimensional conformation. This additional information is to be found in the distribution of observed electron density about the mean position of each atom. It is general practice to account for this by refining a separate atomic displacement parameter (ADP) for each atomic center. However, these same displacements are often described well by simpler models based on TLS (translation/libration/screw) rigid-body motion of large groups of atoms, for example interdomain hinge motion. A procedure, TLSMD, has been developed that analyzes the distribution of ADPs in a previously refined protein crystal structure in order to generate optimal multi-group TLS descriptions of the constituent protein chains. TLSMD is applicable to crystal structures at any resolution. The models generated by TLSMD analysis can significantly improve the standard crystallographic residuals R and R(free) and can reveal intrinsic dynamic properties of the protein.

PubMed: 16552146
DOI: 10.1107/S0907444906005270

実験手法

X-RAY DIFFRACTION (1.7 Å)