3CS4

Structure-based design of a superagonist ligand for the vitamin D nuclear receptor

3CS4 の概要

• エントリーDOI: 10.2210/pdb3cs4/pdb
• 関連するPDBエントリー: 3CS6
• 分子名称: Vitamin D3 receptor, (1S,3R,5Z,7E,14beta,17alpha)-17-[(2S,4S)-4-(2-hydroxy-2-methylpropyl)-2-methyltetrahydrofuran-2-yl]-9,10-secoandrosta-5,7,10-triene-1,3-diol (3 entities in total)
• 機能のキーワード: vdr, superagonist, disease mutation, dna-binding, metal-binding, nucleus, phosphoprotein, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger, gene regulation
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P11473
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30249.99

構造登録者

Hourai, S.,Rodriguez, L.C.,Antony, P.,Reina-San-Martin, B.,Ciesielski, F.,Magnier, B.C.,Schoonjans, K.,Mourino, A.,Rochel, N.,Moras, D. (登録日: 2008-04-09, 公開日: 2008-05-27, 最終更新日: 2024-02-21)

• 主引用文献: Hourai, S.,Rodrigues, L.C.,Antony, P.,Reina-San-Martin, B.,Ciesielski, F.,Magnier, B.C.,Schoonjans, K.,Mourino, A.,Rochel, N.,Moras, D.; Structure-based design of a superagonist ligand for the vitamin d nuclear receptor.; Chem.Biol., 15:383-392, 2008; PubMed: 18420145; DOI: 10.1016/j.chembiol.2008.03.016

実験手法

X-RAY DIFFRACTION (2 Å)