3CPC

Crystal structure of the VEGFR2 kinase domain in complex with a pyridone inhibitor

3CPC の概要

• エントリーDOI: 10.2210/pdb3cpc/pdb
• 関連するPDBエントリー: 3CP9 3CPB
• 分子名称: Vascular endothelial growth factor receptor 2, 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one (3 entities in total)
• 機能のキーワード: receptor tyrosine kinase, angiogenesis, atp-binding, developmental protein, differentiation, glycoprotein, host-virus interaction, immunoglobulin domain, membrane, nucleotide-binding, phosphoprotein, transferase, transmembrane, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 73361.90

構造登録者

Whittington, D.A.,Long, A.M.,Rose, P.,Gu, Y.,Zhao, H. (登録日: 2008-03-31, 公開日: 2008-06-17, 最終更新日: 2024-02-21)

• 主引用文献: Hu, E.,Tasker, A.,White, R.D.,Kunz, R.K.,Human, J.,Chen, N.,Burli, R.,Hungate, R.,Novak, P.,Itano, A.,Zhang, X.,Yu, V.,Nguyen, Y.,Tudor, Y.,Plant, M.,Flynn, S.,Xu, Y.,Meagher, K.L.,Whittington, D.A.,Ng, G.Y.; Discovery of Aryl Aminoquinazoline Pyridones as Potent, Selective, and Orally Efficacious Inhibitors of Receptor Tyrosine Kinase c-Kit.; J.Med.Chem., 51:3065-3068, 2008; PubMed: 18447379; DOI: 10.1021/jm800188g

実験手法

X-RAY DIFFRACTION (2.4 Å)