3CO3

X-Ray Crystal Structure of a Monofunctional Platinum-DNA Adduct, cis-{Pt(NH3)2(pyridine)}2+ Bound to Deoxyguanosine in a Dodecamer Duplex

3CO3 の概要

• エントリーDOI: 10.2210/pdb3co3/pdb
• 分子名称: 5'-D(*DCP*DCP*DTP*DCP*DTP*DCP*DGP*DTP*DCP*DTP*DCP*DC)-3', 5'-D(*DGP*DGP*DAP*DGP*DAP*DCP*DGP*DAP*DGP*DAP*DGP*DG)-3', cis-diammine(pyridine)chloroplatinum(II), ... (4 entities in total)
• 機能のキーワード: platinum-dna duplex, cisplatin, monofunctional pt compound, dna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7670.48

構造登録者

Lovejoy, K.S.,Todd, R.C.,Zhang, S.,McCormick, M.S.,D'Aquino, J.A.,Reardon, J.T.,Sancar, A.,Giacomini, K.M.,Lippard, S.J. (登録日: 2008-03-27, 公開日: 2008-06-10, 最終更新日: 2024-02-21)

• 主引用文献: Lovejoy, K.S.,Todd, R.C.,Zhang, S.,McCormick, M.S.,D'Aquino, J.A.,Reardon, J.T.,Sancar, A.,Giacomini, K.M.,Lippard, S.J.; cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects.; Proc.Natl.Acad.Sci.Usa, 105:8902-8907, 2008; PubMed: 18579768; DOI: 10.1073/pnas.0803441105

実験手法

X-RAY DIFFRACTION (2.16 Å)