3CKE
Crystal structure of aristolochene synthase in complex with 12,13-difluorofarnesyl diphosphate
Summary for 3CKE
Entry DOI | 10.2210/pdb3cke/pdb |
Related | 3BNX 3BNY |
Descriptor | Aristolochene synthase, CHLORIDE ION, (2E,6E)-12-fluoro-11-(fluoromethyl)-3,7-dimethyldodeca-2,6,10-trien-1-yl trihydrogen diphosphate, ... (8 entities in total) |
Functional Keywords | substrate binding, metal ion binding, catalysis, conformational changes, lyase |
Biological source | Aspergillus terreus |
Total number of polymer chains | 4 |
Total formula weight | 147858.16 |
Authors | Shishova, E.Y.,Yu, F.,Miller, D.J.,Faraldos, J.A.,Zhao, Y.,Coates, R.M.,Allemann, R.K.,Cane, D.E.,Christianson, D.W. (deposition date: 2008-03-14, release date: 2008-04-01, Last modification date: 2023-08-30) |
Primary citation | Shishova, E.Y.,Yu, F.,Miller, D.J.,Faraldos, J.A.,Zhao, Y.,Coates, R.M.,Allemann, R.K.,Cane, D.E.,Christianson, D.W. X-ray Crystallographic Studies of Substrate Binding to Aristolochene Synthase Suggest a Metal Ion Binding Sequence for Catalysis. J.Biol.Chem., 283:15431-15439, 2008 Cited by PubMed: 18385128DOI: 10.1074/jbc.M800659200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
Download full validation report