3CJB

Actin dimer cross-linked by V. cholerae MARTX toxin and complexed with Gelsolin-segment 1

3CJB の概要

• エントリーDOI: 10.2210/pdb3cjb/pdb
• 関連するPDBエントリー: 3CJC
• 分子名称: Actin, alpha skeletal muscle, Gelsolin, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: cross-linked dimer, atp-binding, cytoskeleton, methylation, muscle protein, nucleotide-binding, phosphoprotein, structural protein, actin capping, actin-binding, alternative initiation, amyloid, disease mutation, secreted
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm, cytoskeleton: P68135; Isoform 2: Cytoplasm, cytoskeleton. Isoform 1: Secreted: P06396
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 56756.12

構造登録者

Sawaya, M.R.,Kudryashov, D.S.,Pashkov, I.,Reisler, E.,Yeates, T.O. (登録日: 2008-03-12, 公開日: 2008-03-25, 最終更新日: 2024-02-21)

• 主引用文献: Kudryashov, D.S.,Durer, Z.A.,Ytterberg, A.J.,Sawaya, M.R.,Pashkov, I.,Prochazkova, K.,Yeates, T.O.,Loo, R.R.,Loo, J.A.,Satchell, K.J.,Reisler, E.; Connecting actin monomers by iso-peptide bond is a toxicity mechanism of the Vibrio cholerae MARTX toxin.; Proc.Natl.Acad.Sci.USA, 105:18537-18542, 2008; PubMed: 19015515; DOI: 10.1073/pnas.0808082105

実験手法

X-RAY DIFFRACTION (3.21 Å)