3CGH

Crystal structure of a susd homolog (bt_3984) from bacteroides thetaiotaomicron vpi-5482 at 1.70 A resolution

3CGH の概要

• エントリーDOI: 10.2210/pdb3cgh/pdb
• 分子名称: SusD homolog, ZINC ION, ACETATE ION, ... (4 entities in total)
• 機能のキーワード: structural genomics, joint center for structural genomics, jcsg, protein structure initiative, psi-2, metal binding protein
• 由来する生物種: Bacteroides thetaiotaomicron VPI-5482
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 57690.65

構造登録者

Joint Center for Structural Genomics (JCSG) (登録日: 2008-03-05, 公開日: 2008-03-18, 最終更新日: 2024-10-09)

主引用文献

Bakolitsa, C.,Xu, Q.,Rife, C.L.,Abdubek, P.,Astakhova, T.,Axelrod, H.L.,Carlton, D.,Chen, C.,Chiu, H.J.,Clayton, T.,Das, D.,Deller, M.C.,Duan, L.,Ellrott, K.,Farr, C.L.,Feuerhelm, J.,Grant, J.C.,Grzechnik, A.,Han, G.W.,Jaroszewski, L.,Jin, K.K.,Klock, H.E.,Knuth, M.W.,Kozbial, P.,Krishna, S.S.,Kumar, A.,Lam, W.W.,Marciano, D.,McMullan, D.,Miller, M.D.,Morse, A.T.,Nigoghossian, E.,Nopakun, A.,Okach, L.,Puckett, C.,Reyes, R.,Tien, H.J.,Trame, C.B.,van den Bedem, H.,Weekes, D.,Hodgson, K.O.,Wooley, J.,Elsliger, M.A.,Deacon, A.M.,Godzik, A.,Lesley, S.A.,Wilson, I.A.
Structure of BT_3984, a member of the SusD/RagB family of nutrient-binding molecules.
Acta Crystallogr.,Sect.F, 66:1274-1280, 2010

PubMed Abstract: The crystal structure of the Bacteroides thetaiotaomicron protein BT_3984 was determined to a resolution of 1.7 Å and was the first structure to be determined from the extensive SusD family of polysaccharide-binding proteins. SusD is an essential component of the sus operon that defines the paradigm for glycan utilization in dominant members of the human gut microbiota. Structural analysis of BT_3984 revealed an N-terminal region containing several tetratricopeptide repeats (TPRs), while the signature C-terminal region is less structured and contains extensive loop regions. Sequence and structure analysis of BT_3984 suggests the presence of binding interfaces for other proteins from the polysaccharide-utilization complex.

PubMed: 20944222
DOI: 10.1107/S1744309110032999

実験手法

X-RAY DIFFRACTION (1.7 Å)