3CE3

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with a Pyrrolopyridinepyridone based inhibitor

3CE3 の概要

• エントリーDOI: 10.2210/pdb3ce3/pdb
• 関連するPDBエントリー: 3C1X
• 分子名称: Hepatocyte growth factor receptor, 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide (3 entities in total)
• 機能のキーワード: receptor tyrosine kinase, signal transduction, grb2, shc, atp-binding, glycoprotein, membrane, nucleotide-binding, phosphoprotein, proto-oncogene, transferase, transmembrane, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P08581
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35893.45

構造登録者

Sack, J. (登録日: 2008-02-28, 公開日: 2008-08-26, 最終更新日: 2024-02-21)

• 主引用文献: Kim, K.S.,Zhang, L.,Schmidt, R.,Cai, Z.W.,Wei, D.,Williams, D.K.,Lombardo, L.J.,Trainor, G.L.,Xie, D.,Zhang, Y.,An, Y.,Sack, J.S.,Tokarski, J.S.,Darienzo, C.,Kamath, A.,Marathe, P.,Zhang, Y.,Lippy, J.,Jeyaseelan, R.,Wautlet, B.,Henley, B.,Gullo-Brown, J.,Manne, V.,Hunt, J.T.,Fargnoli, J.,Borzilleri, R.M.; Discovery of pyrrolopyridine-pyridone based inhibitors of Met kinase: synthesis, X-ray crystallographic analysis, and biological activities.; J.Med.Chem., 51:5330-5341, 2008; PubMed: 18690676; DOI: 10.1021/jm800476q

実験手法

X-RAY DIFFRACTION (2.4 Å)