3CAJ
Crystal structure of the human carbonic anhydrase II in complex with ethoxzolamide
Summary for 3CAJ
Entry DOI | 10.2210/pdb3caj/pdb |
Related | 1A42 1CA2 1CIL |
Descriptor | Carbonic anhydrase 2, ZINC ION, CHLORIDE ION, ... (7 entities in total) |
Functional Keywords | protein-inhibitor complex, disease mutation, lyase, metal-binding |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 30062.04 |
Authors | Di Fiore, A.,De Simone, G. (deposition date: 2008-02-20, release date: 2008-04-08, Last modification date: 2023-11-01) |
Primary citation | Di Fiore, A.,Pedone, C.,Antel, J.,Waldeck, H.,Witte, A.,Wurl, M.,Scozzafava, A.,Supuran, C.T.,De Simone, G. Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors Bioorg.Med.Chem.Lett., 18:2669-2674, 2008 Cited by PubMed: 18359629DOI: 10.1016/j.bmcl.2008.03.023 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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