3C56

Class II fructose-1,6-bisphosphate aldolase from helicobacter pylori in complex with N-(3-Hydroxypropyl)-glycolohydroxamic acid bisphosphate, a competitive inhibitor

3C56 の概要

• エントリーDOI: 10.2210/pdb3c56/pdb
• 関連するPDBエントリー: 3C4U 3C52
• 分子名称: Fructose-bisphosphate aldolase, ZINC ION, 3-{hydroxy[(phosphonooxy)acetyl]amino}propyl dihydrogen phosphate, ... (4 entities in total)
• 機能のキーワード: class ii, fbp, aldolase, glycolysis, inhibitor, lyase, metal-binding, zinc
• 由来する生物種: Helicobacter pylori
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68350.65

構造登録者

Coincon, M.,Sygusch, J.,Potvin-Dulude, P. (登録日: 2008-01-30, 公開日: 2008-08-26, 最終更新日: 2024-04-03)

主引用文献

Fonvielle, M.,Coincon, M.,Daher, R.,Desbenoit, N.,Kosieradzka, K.,Barilone, N.,Gicquel, B.,Sygusch, J.,Jackson, M.,Therisod, M.
Synthesis and Biochemical Evaluation of Selective Inhibitors of Class II Fructose Bisphosphate Aldolases: Towards New Synthetic Antibiotics.
Chemistry, 14:8521-8529, 2008

PubMed Abstract: We report the synthesis and biochemical evaluation of selective inhibitors of class II (zinc-dependent) fructose bisphosphate aldolases. The most active compound is a simplified analogue of fructose bisphosphate, bearing a well-positioned metal chelating group. It is a powerful and highly selective competitive inhibitor of isolated class II aldolases. We report crystallographic studies of this inhibitor bound in the active site of the Helicobacter pylori enzyme. The compound also shows activity against Mycobacterium tuberculosis isolates.

PubMed: 18688832
DOI: 10.1002/chem.200800857

実験手法

X-RAY DIFFRACTION (2.3 Å)