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3BXR

Crystal Structures Of Highly Constrained Substrate And Hydrolysis Products Bound To HIV-1 Protease. Implications For Catalytic Mechanism

Summary for 3BXR
Entry DOI10.2210/pdb3bxr/pdb
Related1B6P
DescriptorProtease, SULFATE ION, (9S,12S)-9-(1-methylethyl)-N-[(8S,11S)-8-[(1S)-1-methylpropyl]-7,10-dioxo-2-oxa-6,9-diazabicyclo[11.2.2]heptadeca-1(15),13,16-trien-11-yl]-7,10-dioxo-2-oxa-8,11-diazabicyclo[12.2.2]octadeca-1(16),14,17-triene-12-carboxamide, ... (4 entities in total)
Functional Keywordshiv protease, hivpr, substrate, product, aids, aspartyl protease, capsid maturation, core protein, cytoplasm, dna integration, dna recombination, dna-directed dna polymerase, endonuclease, hydrolase, lipoprotein, magnesium, membrane, metal-binding, multifunctional enzyme, myristate, nuclease, nucleotidyltransferase, nucleus, phosphoprotein, rna-binding, rna-directed dna polymerase, transferase, viral nucleoprotein, virion, zinc, zinc-finger
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
Total number of polymer chains2
Total formula weight22591.48
Authors
Tyndall, J.D.,Pattenden, L.K.,Reid, R.C.,Hu, S.H.,Alewood, D.,Alewood, P.F.,Walsh, T.,Fairlie, D.P.,Martin, J.L. (deposition date: 2008-01-14, release date: 2008-03-25, Last modification date: 2023-11-15)
Primary citationTyndall, J.D.,Pattenden, L.K.,Reid, R.C.,Hu, S.H.,Alewood, D.,Alewood, P.F.,Walsh, T.,Fairlie, D.P.,Martin, J.L.
Crystal Structures of Highly Constrained Substrate and Hydrolysis Products Bound to HIV-1 Protease. Implications for the Catalytic Mechanism
Biochemistry, 47:3736-3744, 2008
Cited by
PubMed: 18311928
DOI: 10.1021/bi7023157
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.6 Å)
Structure validation

217705

数据于2024-03-27公开中

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