3BT6

Crystal Structure of Influenza B Virus Hemagglutinin

3BT6 の概要

• エントリーDOI: 10.2210/pdb3bt6/pdb
• 関連するPDBエントリー: 2RFT 2RFU
• 分子名称: Influenza B hemagglutinin (HA), 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: antigenic variation, membrane fusion, envelope protein, fusion protein, hemagglutinin, transmembrane, virion, glycoprotein, lipoprotein, palmitate, viral protein
• 由来する生物種: Influenza B virus; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 57610.04

構造登録者

Wang, Q.,Cheng, F.,Lu, M.,Tian, X.,Ma, J. (登録日: 2007-12-27, 公開日: 2008-05-27, 最終更新日: 2024-10-30)

主引用文献

Wang, Q.,Cheng, F.,Lu, M.,Tian, X.,Ma, J.
Crystal structure of unliganded influenza B virus hemagglutinin.
J.Virol., 82:3011-3020, 2008

PubMed Abstract: Here we report the crystal structure of hemagglutinin (HA) from influenza B/Hong Kong/8/73 (B/HK) virus determined to 2.8 A. At a sequence identity of approximately 25% to influenza A virus HAs, B/HK HA shares a similar overall structure and domain organization. More than two dozen amino acid substitutions on influenza B virus HAs have been identified to cause antigenicity alteration in site-specific mutants, monoclonal antibody escape mutants, or field isolates. Mapping these substitutions on the structure of B/HK HA reveals four major epitopes, the 120 loop, the 150 loop, the 160 loop, and the 190 helix, that are located close in space to form a large, continuous antigenic site. Moreover, a systematic comparison of known HA structures across the entire influenza virus family reveals evolutionarily conserved ionizable residues at all regions along the chain and subunit interfaces. These ionizable residues are likely the structural basis for the pH dependence and sensitivity to ionic strength of influenza HA and hemagglutinin-esterase fusion proteins.

PubMed: 18184701
DOI: 10.1128/JVI.02477-07

実験手法

X-RAY DIFFRACTION (2.8 Å)