3BSN

Norwalk Virus polymerase bound to 5-nitrocytidine triphosphate and primer-template RNA

Summary for 3BSN

• Entry DOI: 10.2210/pdb3bsn/pdb
• Related: 1SH0 3BSO
• Descriptor: RNA dependent RNA polymerase, RNA (5'-R(*UP*GP*CP*CP*CP*GP*GP*G)-3'), RNA (5'-R(*UP*GP*CP*CP*CP*GP*GP*GP*(N5M))-3'), ... (7 entities in total)
• Functional Keywords: rna-dependent rna polymerase, viral replication, antiviral enzyme inhibitor, helicase, hydrolase, nucleotide-binding, nucleotidyltransferase, rna replication, rna-directed rna polymerase, transferase, transferase-rna complex, transferase/rna
• Biological source: Norwalk virus; More
• Total number of polymer chains: 3
• Total formula weight: 63370.25

Authors

Zamyatkin, D.F.,Ng, K.K.S. (deposition date: 2007-12-26, release date: 2008-01-08, Last modification date: 2023-08-30)

• Primary citation: Zamyatkin, D.F.,Parra, F.,Alonso, J.M.,Harki, D.A.,Peterson, B.R.,Grochulski, P.,Ng, K.K.; Structural insights into mechanisms of catalysis and inhibition in norwalk virus polymerase.; J.Biol.Chem., 283:7705-7712, 2008; PubMed: 18184655; DOI: 10.1074/jbc.M709563200

Experimental method

X-RAY DIFFRACTION (1.8 Å)