3BRB

Crystal structure of catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with ADP

3BRB の概要

• エントリーDOI: 10.2210/pdb3brb/pdb
• 関連するPDBエントリー: 2P0C 3BPR
• 分子名称: Proto-oncogene tyrosine-protein kinase MER, CHLORIDE ION, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: atp-binding, disease mutation, glycoprotein, kinase, nucleotide-binding, phosphorylation, proto-oncogene, receptor, retinitis pigmentosa, sensory transduction, transferase, tyrosine-protein kinase, vision, structural genomics, structural genomics consortium, sgc, immunoglobulin domain, membrane, phosphoprotein, transmembrane
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein (By similarity): Q12866
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72951.24

構造登録者

Walker, J.R.,Huang, X.,Finerty Jr, P.J.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Dhe-Paganon, S.,Structural Genomics Consortium (SGC) (登録日: 2007-12-21, 公開日: 2008-01-22, 最終更新日: 2023-08-30)

• 主引用文献: Huang, X.,Finerty, P.,Walker, J.R.,Butler-Cole, C.,Vedadi, M.,Schapira, M.,Parker, S.A.,Turk, B.E.,Thompson, D.A.,Dhe-Paganon, S.; Structural insights into the inhibited states of the Mer receptor tyrosine kinase.; J.Struct.Biol., 165:88-96, 2009; PubMed: 19028587; DOI: 10.1016/j.jsb.2008.10.003

実験手法

X-RAY DIFFRACTION (1.9 Å)