3BQP

Crystal Structure of Human Saposin D (orthorhombic)

3BQP の概要

• エントリーDOI: 10.2210/pdb3bqp/pdb
• 関連するPDBエントリー: 3BQQ
• 分子名称: Proactivator polypeptide, MAGNESIUM ION (3 entities in total)
• 機能のキーワード: saposin, sphingolipid activator protein, lipid binding protein, acid ceramidase, farber disease, lipid metabolism, lysosome, sphingolipid metabolism
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Lysosome: P07602
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 17925.58

構造登録者

Prive, G.G.,Popovic, K. (登録日: 2007-12-20, 公開日: 2008-02-05, 最終更新日: 2024-10-30)

主引用文献

Popovic, K.,Prive, G.G.
Structures of the human ceramide activator protein saposin D.
Acta Crystallogr.,Sect.D, 64:589-594, 2008

PubMed Abstract: Saposin D is a sphingolipid activator protein required for the lysosomal breakdown of ceramide to a fatty acid and sphingosine by acid ceramidase. The crystal structure of saposin D has been determined in two different crystal forms, resulting in a total of six crystallographically independent views of this small 80-amino-acid protein. All of the structures are highly similar and reveal the monomeric form of the saposin fold previously seen in the crystal structures of saposins A and C. Saposin D is slightly more compact than the related saposins A and C owing to a slight repositioning of the 'stem' and 'hairpin' regions of the protein.

PubMed: 18453694
DOI: 10.1107/S0907444908003120

実験手法

X-RAY DIFFRACTION (1.3 Å)