3BPS

PCSK9:EGF-A complex

3BPS の概要

• エントリーDOI: 10.2210/pdb3bps/pdb
• 分子名称: Proprotein convertase subtilisin/kexin type 9, Low-density lipoprotein receptor, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: pcsk9, ldl receptor, autocatalytic cleavage, cholesterol metabolism, disease mutation, glycoprotein, hydrolase, lipid metabolism, phosphoprotein, protease, secreted, serine protease, steroid metabolism, zymogen, coated pit, egf-like domain, endocytosis, host-virus interaction, lipid transport, membrane, transmembrane, transport, hydrolase-lipid transport complex, hydrolase/lipid transport
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: Q8NBP7 Q8NBP7; Cell membrane; Single-pass type I membrane protein: P01130
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 77857.85

構造登録者

Kwon, H.J. (登録日: 2007-12-19, 公開日: 2008-02-12, 最終更新日: 2023-08-30)

• 主引用文献: Kwon, H.J.,Lagace, T.A.,McNutt, M.C.,Horton, J.D.,Deisenhofer, J.; Molecular basis for LDL receptor recognition by PCSK9.; Proc.Natl.Acad.Sci.Usa, 105:1820-1825, 2008; PubMed: 18250299; DOI: 10.1073/pnas.0712064105

実験手法

X-RAY DIFFRACTION (2.41 Å)