3BLT

Crystal structures of YopH complexed with PVSN and PVS, inhibitors of YopH which co-valent bind to Cys of active site

3BLT の概要

• エントリーDOI: 10.2210/pdb3blt/pdb
• 関連するPDBエントリー: 3BLU
• 分子名称: Tyrosine-protein phosphatase yopH, phenyl ethenesulfonate (3 entities in total)
• 機能のキーワード: co-valent binding, binding affinity, binding selectivity, hydrolase, membrane, outer membrane, plasmid, protein phosphatase, secreted, virulence
• 由来する生物種: Yersinia enterocolitica
• 細胞内の位置: Secreted: P15273
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33606.90

構造登録者

Liu, S.,Zhang, Z.-Y. (登録日: 2007-12-11, 公開日: 2009-02-10, 最終更新日: 2023-08-30)

• 主引用文献: Liu, S.,Zhou, B.,Yang, H.,He, Y.,Jiang, Z.X.,Kumar, S.,Wu, L.,Zhang, Z.Y.; Aryl vinyl sulfonates and sulfones as active site-directed and mechanism-based probes for protein tyrosine phosphatases.; J.Am.Chem.Soc., 130:8251-8260, 2008; PubMed: 18528979; DOI: 10.1021/ja711125p

実験手法

X-RAY DIFFRACTION (2.2 Å)