3BL7

Synthetic Gene Encoded DcpS bound to inhibitor DG156844

3BL7 の概要

• エントリーDOI: 10.2210/pdb3bl7/pdb
• 関連するPDBエントリー: 1ST0 1ST4 3BL9 3BLA
• 分子名称: Scavenger mRNA-decapping enzyme DcpS, 5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine (3 entities in total)
• 機能のキーワード: mrna decapping enzyme, dcps, ligand complex, cytoplasm, hydrolase, nonsense-mediated mrna decay, nucleus, polymorphism, structural genomics, psi-2, protein structure initiative, accelerated technologies center for gene to 3d structure, atcg3d
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: Q96C86
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70164.67

構造登録者

Staker, B.L.,Christensen, J.,Stewart, L.,Accelerated Technologies Center for Gene to 3D Structure (ATCG3D) (登録日: 2007-12-10, 公開日: 2008-10-21, 最終更新日: 2023-08-30)

• 主引用文献: Singh, J.,Salcius, M.,Liu, S.W.,Staker, B.L.,Mishra, R.,Thurmond, J.,Michaud, G.,Mattoon, D.R.,Printen, J.,Christensen, J.,Bjornsson, J.M.,Pollok, B.A.,Kiledjian, M.,Stewart, L.,Jarecki, J.,Gurney, M.E.; DcpS as a therapeutic target for spinal muscular atrophy.; Acs Chem.Biol., 3:711-722, 2008; PubMed: 18839960; DOI: 10.1021/cb800120t

実験手法

X-RAY DIFFRACTION (2.31 Å)