3BL0
Carbonic anhydrase inhibitors. Interaction of 2-N,N-Dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies
Summary for 3BL0
Entry DOI | 10.2210/pdb3bl0/pdb |
Related | 2EU2 2EU3 3BL1 |
Descriptor | Carbonic anhydrase 2, ZINC ION, 1-[5-(dimethylamino)-1,3,4-thiadiazol-2-yl]methanesulfonamide, ... (5 entities in total) |
Functional Keywords | carbonic anhydrase, inhibitors, sulfonamide, acetylation, cytoplasm, disease mutation, lyase, metal-binding, polymorphism, zinc, lyase(oxo-acid) |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29898.46 |
Authors | Temperini, C.,Supuran, C.T.,Blackburn, G.M. (deposition date: 2007-12-10, release date: 2008-01-22, Last modification date: 2024-02-21) |
Primary citation | Temperini, C.,Cecchi, A.,Boyle, N.A.,Scozzafava, A.,Cabeza, J.E.,Wentworth, P.,Blackburn, G.M.,Supuran, C.T. Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies. Bioorg.Med.Chem.Lett., 18:999-1005, 2008 Cited by PubMed: 18162396DOI: 10.1016/j.bmcl.2007.12.022 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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