3BL0

Carbonic anhydrase inhibitors. Interaction of 2-N,N-Dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies

3BL0 の概要

• エントリーDOI: 10.2210/pdb3bl0/pdb
• 関連するPDBエントリー: 2EU2 2EU3 3BL1
• 分子名称: Carbonic anhydrase 2, ZINC ION, 1-[5-(dimethylamino)-1,3,4-thiadiazol-2-yl]methanesulfonamide, ... (5 entities in total)
• 機能のキーワード: carbonic anhydrase, inhibitors, sulfonamide, acetylation, cytoplasm, disease mutation, lyase, metal-binding, polymorphism, zinc, lyase(oxo-acid)
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29898.46

構造登録者

Temperini, C.,Supuran, C.T.,Blackburn, G.M. (登録日: 2007-12-10, 公開日: 2008-01-22, 最終更新日: 2024-02-21)

• 主引用文献: Temperini, C.,Cecchi, A.,Boyle, N.A.,Scozzafava, A.,Cabeza, J.E.,Wentworth, P.,Blackburn, G.M.,Supuran, C.T.; Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.; Bioorg.Med.Chem.Lett., 18:999-1005, 2008; PubMed: 18162396; DOI: 10.1016/j.bmcl.2007.12.022

実験手法

X-RAY DIFFRACTION (1.9 Å)