3BJP

Urate oxidase cyanide uric acid ternary complex

3BJP の概要

• エントリーDOI: 10.2210/pdb3bjp/pdb
• 関連するPDBエントリー: 1R4S 1R4U 1R51 1R56 1WRR 1WS2
• 分子名称: Uricase, SODIUM ION, CYANIDE ION, ... (6 entities in total)
• 機能のキーワード: uric acid, cyanide, inhibition, degradation mechanism, acetylation, oxidoreductase, peroxisome, purine metabolism
• 由来する生物種: Aspergillus flavus
• 細胞内の位置: Peroxisome: Q00511
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34418.72

構造登録者

Gabison, L.,Prange, T.,Colloc'h, N.,El Hajji, M.,Castro, B.,Chiadmi, M. (登録日: 2007-12-04, 公開日: 2008-08-12, 最終更新日: 2023-11-01)

主引用文献

Gabison, L.,Prange, T.,Colloc'h, N.,El Hajji, M.,Castro, B.,Chiadmi, M.
Structural analysis of urate oxidase in complex with its natural substrate inhibited by cyanide: Mechanistic implications
Bmc Struct.Biol., 8:32-32, 2008

PubMed Abstract: Urate oxidase (EC 1.7.3.3 or UOX) catalyzes the conversion of uric acid and gaseous molecular oxygen to 5-hydroxyisourate and hydrogen peroxide, in the absence of cofactor or particular metal cation. The functional enzyme is a homo-tetramer with four active sites located at dimeric interfaces.

PubMed: 18638417
DOI: 10.1186/1472-6807-8-32

実験手法

X-RAY DIFFRACTION (1.8 Å)