3BJM

Crystal structure of human DPP-IV in complex with (1S,3S, 5S)-2-[(2S)-2-AMINO-2-(3-HYDROXYTRICYCLO[3.3.1.13,7]DEC-1- YL)ACETYL]-2-AZABICYCLO[3.1.0]HEXANE-3-CARBONITRILE (CAS), (1S,3S,5S)-2-((2S)-2-AMINO-2-(3-HYDROXYADAMANTAN-1- YL)ACETYL)-2-AZABICYCLO[3.1.0]HEXANE-3-CARBONITRILE (IUPAC), OR BMS-477118

3BJM の概要

• エントリーDOI: 10.2210/pdb3bjm/pdb
• 関連するPDBエントリー: 3NOX 3Q0T 3SWW 3SX4
• 分子名称: Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose, (2~{S})-2-azanyl-1-[(1~{S},3~{S},5~{S})-3-(iminomethyl)-2-azabicyclo[3.1.0]hexan-2-yl]-2-[(5~{R},7~{S})-3-oxidanyl-1-ad amantyl]ethanone, ... (4 entities in total)
• 機能のキーワード: exopeptidase, alpha/beta hydrolase fold, beta barrel, beta propeller, dpp4, dimer, protein:inhibitor complex, aminopeptidase, glycoprotein, membrane, protease, secreted, serine protease, signal-anchor, transmembrane, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 171329.75

構造登録者

Klei, H.E. (登録日: 2007-12-04, 公開日: 2008-04-22, 最終更新日: 2020-07-29)

• 主引用文献: Metzler, W.J.,Yanchunas, J.,Weigelt, C.,Kish, K.,Klei, H.E.,Xie, D.,Zhang, Y.,Corbett, M.,Tamura, J.K.,He, B.,Hamann, L.G.,Kirby, M.S.,Marcinkeviciene, J.; Involvement of DPP-IV catalytic residues in enzyme-saxagliptin complex formation.; Protein Sci., 17:240-250, 2008; PubMed: 18227430; DOI: 10.1110/ps.073253208

実験手法

X-RAY DIFFRACTION (2.35 Å)