3BIZ
Wee1 kinase complex with inhibitor PD331618
Summary for 3BIZ
Entry DOI | 10.2210/pdb3biz/pdb |
Related | 1X8B |
Descriptor | Wee1-like protein kinase, CHLORIDE ION, 4-(2-chlorophenyl)-8-[3-(dimethylamino)propoxy]-9-hydroxy-6-methylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione, ... (4 entities in total) |
Functional Keywords | kinase domain, inhibitor complex, atp-binding, cell cycle, cell division, magnesium, metal-binding, mitosis, nucleotide-binding, nucleus, phosphoprotein, transferase, tyrosine-protein kinase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P30291 |
Total number of polymer chains | 1 |
Total formula weight | 32810.16 |
Authors | Squire, C.J.,Dickson, J.M.,Ivanovic, I.,Baker, E.N. (deposition date: 2007-12-02, release date: 2007-12-25, Last modification date: 2023-11-01) |
Primary citation | Smaill, J.B.,Lee, H.H.,Palmer, B.D.,Thompson, A.M.,Squire, C.J.,Baker, E.N.,Booth, R.J.,Kraker, A.,Hook, K.,Denny, W.A. Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases. Bioorg.Med.Chem.Lett., 18:929-933, 2008 Cited by PubMed: 18191399DOI: 10.1016/j.bmcl.2007.12.046 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report