3BI9

Tim-4

3BI9 の概要

• エントリーDOI: 10.2210/pdb3bi9/pdb
• 関連するPDBエントリー: 2or7 2or8 2oyp 3BIA 3BIB
• 分子名称: T-cell immunoglobulin and mucin domain-containing protein 4, ACETATE ION (3 entities in total)
• 機能のキーワード: beta barrel, immunoglobulin fold, igv domain, tim, glycoprotein, immunoglobulin domain, membrane, polymorphism, transmembrane, immune system
• 由来する生物種: Mus musculus (house mouse)
• 細胞内の位置: Membrane; Single-pass type I membrane protein (Potential): Q6U7R4
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13238.18

構造登録者

Santiago, C.,Ballesteros, A.,Kaplan, G.G.,Freeman, G.J.,Casasnovas, J.M. (登録日: 2007-11-30, 公開日: 2008-01-01, 最終更新日: 2024-10-30)

主引用文献

Santiago, C.,Ballesteros, A.,Martinez-Munoz, L.,Mellado, M.,Kaplan, G.G.,Freeman, G.J.,Casasnovas, J.M.
Structures of T Cell Immunoglobulin Mucin Protein 4 Show a Metal-Ion-Dependent Ligand Binding Site where Phosphatidylserine Binds.
Immunity, 27:941-951, 2007

PubMed Abstract: The T cell immunoglobulin and mucin domain (TIM) proteins are important regulators of T cell responses. Crystal structures of the murine TIM-4 identified a metal-ion-dependent ligand binding site (MILIBS) in the immunoglobulin (Ig) domain of the TIM family. The characteristic CC' loop of the TIM domain and the hydrophobic FG loop shaped a narrow cavity where acidic compounds penetrate and coordinate to a metal ion bound to conserved residues in the TIM proteins. The structure of phosphatidylserine bound to the Ig domain showed that the hydrophilic head penetrates into the MILIBS and coordinates with the metal ion, whereas the aromatic residues on the tip of the FG loop interacted with the fatty acid chains and could insert into the lipid bilayer. Our results also revealed an important role of the MILIBS in the trafficking of TIM-1 to the cell surface.

PubMed: 18083575
DOI: 10.1016/j.immuni.2007.11.008

実験手法

X-RAY DIFFRACTION (2.95 Å)