3BHY

Crystal structure of human death associated protein kinase 3 (DAPK3) in complex with a beta-carboline ligand

3BHY の概要

• エントリーDOI: 10.2210/pdb3bhy/pdb
• 分子名称: Death-associated protein kinase 3, CHLORIDE ION, (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile, ... (4 entities in total)
• 機能のキーワード: death associated kinase, dapk3, zip kinase, zipk, dap kinase 3, dap like kinase, dlk, structural genomics consortium, sgc, apoptosis, atp-binding, chromatin regulator, nucleotide-binding, nucleus, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus . Isoform 1: Nucleus . Isoform 2: Nucleus : O43293
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32957.84

構造登録者

Filippakopoulos, P.,Rellos, P.,Eswaran, J.,Fedorov, O.,Berridge, G.,Niesen, F.,Bracher, F.,Huber, K.,Pike, A.C.W.,Roos, A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2007-11-29, 公開日: 2007-12-25, 最終更新日: 2023-08-30)

• 主引用文献: Huber, K.,Brault, L.,Fedorov, O.,Gasser, C.,Filippakopoulos, P.,Bullock, A.N.,Fabbro, D.,Trappe, J.,Schwaller, J.,Knapp, S.,Bracher, F.; 7,8-dichloro-1-oxo-beta-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes.; J.Med.Chem., 55:403-413, 2012; PubMed: 22136433; DOI: 10.1021/jm201286z

実験手法

X-RAY DIFFRACTION (1.24 Å)