3BGQ

Human Pim-1 kinase in complex with an triazolo pyridazine inhibitor VX2

3BGQ の概要

• エントリーDOI: 10.2210/pdb3bgq/pdb
• 関連するPDBエントリー: 3BGP 3BGZ
• 分子名称: Proto-oncogene serine/threonine-protein kinase Pim-1, N-cyclohexyl-3-[3-(trifluoromethyl)phenyl][1,2,4]triazolo[4,3-b]pyridazin-6-amine (3 entities in total)
• 機能のキーワード: kinase inhibitor phosphorylation, alternative initiation, atp-binding, cytoplasm, manganese, membrane, metal-binding, nucleotide-binding, nucleus, phosphoprotein, proto-oncogene, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38345.44

構造登録者

Jacobs, M.D. (登録日: 2007-11-27, 公開日: 2007-12-11, 最終更新日: 2011-07-13)

• 主引用文献: Pierce, A.C.,Jacobs, M.,Stuver-Moody, C.; Docking study yields four novel inhibitors of the protooncogene pim-1 kinase.; J.Med.Chem., 51:1972-1975, 2008; PubMed: 18290603; DOI: 10.1021/jm701248t

実験手法

X-RAY DIFFRACTION (2 Å)