3BG8

Crystal structure of Factor XIa in complex with Clavatadine A

Summary for 3BG8

Entry DOI	10.2210/pdb3bg8/pdb
Descriptor	Coagulation factor XIa light chain, N-(4-carbamimidamidobutyl)ethanamide, BENZAMIDINE, ... (5 entities in total)
Functional Keywords	protease inhibitor, factor xia inhibitor complex, covalent inhibitor, alternative splicing, blood coagulation, disease mutation, glycoprotein, heparin-binding, hydrolase, polymorphism, secreted, serine protease
Biological source	Homo sapiens (Human)
Cellular location	Secreted: P03951
Total number of polymer chains	1
Total formula weight	27643.22
Authors	Xue, Y.,Oster, L. (deposition date: 2007-11-26, release date: 2008-12-09, Last modification date: 2021-10-13)
Primary citation	Buchanan, M.S.,Carroll, A.R.,Wessling, D.,Jobling, M.,Avery, V.M.,Davis, R.A.,Feng, Y.,Xue, Y.,Oster, L.,Fex, T.,Deinum, J.,Hooper, J.N.,Quinn, R.J. Clavatadine A, a natural product with selective recognition and irreversible inhibition of factor XIa. J.Med.Chem., 51:3583-3587, 2008 Cited by PubMed: 18510371 DOI: 10.1021/jm800314b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation