3BG8
Crystal structure of Factor XIa in complex with Clavatadine A
Summary for 3BG8
Entry DOI | 10.2210/pdb3bg8/pdb |
Descriptor | Coagulation factor XIa light chain, N-(4-carbamimidamidobutyl)ethanamide, BENZAMIDINE, ... (5 entities in total) |
Functional Keywords | protease inhibitor, factor xia inhibitor complex, covalent inhibitor, alternative splicing, blood coagulation, disease mutation, glycoprotein, heparin-binding, hydrolase, polymorphism, secreted, serine protease |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted: P03951 |
Total number of polymer chains | 1 |
Total formula weight | 27643.22 |
Authors | |
Primary citation | Buchanan, M.S.,Carroll, A.R.,Wessling, D.,Jobling, M.,Avery, V.M.,Davis, R.A.,Feng, Y.,Xue, Y.,Oster, L.,Fex, T.,Deinum, J.,Hooper, J.N.,Quinn, R.J. Clavatadine A, a natural product with selective recognition and irreversible inhibition of factor XIa. J.Med.Chem., 51:3583-3587, 2008 Cited by PubMed: 18510371DOI: 10.1021/jm800314b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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