3BG8

Crystal structure of Factor XIa in complex with Clavatadine A

3BG8 の概要

• エントリーDOI: 10.2210/pdb3bg8/pdb
• 分子名称: Coagulation factor XIa light chain, N-(4-carbamimidamidobutyl)ethanamide, BENZAMIDINE, ... (5 entities in total)
• 機能のキーワード: protease inhibitor, factor xia inhibitor complex, covalent inhibitor, alternative splicing, blood coagulation, disease mutation, glycoprotein, heparin-binding, hydrolase, polymorphism, secreted, serine protease
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Secreted: P03951
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27643.22

構造登録者

Xue, Y.,Oster, L. (登録日: 2007-11-26, 公開日: 2008-12-09, 最終更新日: 2021-10-13)

• 主引用文献: Buchanan, M.S.,Carroll, A.R.,Wessling, D.,Jobling, M.,Avery, V.M.,Davis, R.A.,Feng, Y.,Xue, Y.,Oster, L.,Fex, T.,Deinum, J.,Hooper, J.N.,Quinn, R.J.; Clavatadine A, a natural product with selective recognition and irreversible inhibition of factor XIa.; J.Med.Chem., 51:3583-3587, 2008; PubMed: 18510371; DOI: 10.1021/jm800314b

実験手法

X-RAY DIFFRACTION (1.6 Å)