3BCH

Crystal Structure of the Human Laminin Receptor Precursor

Summary for 3BCH

Entry DOI	10.2210/pdb3bch/pdb
Descriptor	40S ribosomal protein SA (2 entities in total)
Functional Keywords	laminin receptor, p40 ribosomal protein, acetylation, cytoplasm, phosphorylation, polymorphism, ribonucleoprotein, cell adhesion, ribosomal protein
Biological source	Homo sapiens (human)
Cellular location	Cell membrane: P08865
Total number of polymer chains	1
Total formula weight	28205.04
Authors	Jamieson, K.V.,Wu, J.,Hubbard, S.R.,Meruelo, D. (deposition date: 2007-11-12, release date: 2007-12-04, Last modification date: 2024-02-21)
Primary citation	Jamieson, K.V.,Wu, J.,Hubbard, S.R.,Meruelo, D. Crystal structure of the human laminin receptor precursor. J.Biol.Chem., 283:3002-3005, 2008 Cited by PubMed Abstract: The human laminin receptor (LamR) interacts with many ligands, including laminin, prions, Sindbis virus, and the polyphenol (-)-epigallocatechin-3-gallate (EGCG), and has been implicated in a number of diseases. LamR is overexpressed on tumor cells, and targeting LamR elicits anti-cancer effects. Here, we report the crystal structure of human LamR, which provides insights into its function and should facilitate the design of novel therapeutics targeting LamR. PubMed: 18063583 DOI: 10.1074/jbc.C700206200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation