3BCH

Crystal Structure of the Human Laminin Receptor Precursor

3BCH の概要

• エントリーDOI: 10.2210/pdb3bch/pdb
• 分子名称: 40S ribosomal protein SA (2 entities in total)
• 機能のキーワード: laminin receptor, p40 ribosomal protein, acetylation, cytoplasm, phosphorylation, polymorphism, ribonucleoprotein, cell adhesion, ribosomal protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane: P08865
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28205.04

構造登録者

Jamieson, K.V.,Wu, J.,Hubbard, S.R.,Meruelo, D. (登録日: 2007-11-12, 公開日: 2007-12-04, 最終更新日: 2024-02-21)

主引用文献

Jamieson, K.V.,Wu, J.,Hubbard, S.R.,Meruelo, D.
Crystal structure of the human laminin receptor precursor.
J.Biol.Chem., 283:3002-3005, 2008

PubMed Abstract: The human laminin receptor (LamR) interacts with many ligands, including laminin, prions, Sindbis virus, and the polyphenol (-)-epigallocatechin-3-gallate (EGCG), and has been implicated in a number of diseases. LamR is overexpressed on tumor cells, and targeting LamR elicits anti-cancer effects. Here, we report the crystal structure of human LamR, which provides insights into its function and should facilitate the design of novel therapeutics targeting LamR.

PubMed: 18063583
DOI: 10.1074/jbc.C700206200

実験手法

X-RAY DIFFRACTION (2.15 Å)