3B92
Novel thio-based TACE inhibitors Part 2: Rational design, synthesis and SAR of thiol-contaning aryl sufones
3B92 の概要
エントリーDOI | 10.2210/pdb3b92/pdb |
分子名称 | ADAM 17, ZINC ION, 3-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}propane-1-thiol, ... (4 entities in total) |
機能のキーワード | tnf-alpha converting enzyme, aryl-sulfonamide, tace inhibitors, alternative splicing, cleavage on pair of basic residues, glycoprotein, hydrolase, membrane, metal-binding, metalloprotease, notch signaling pathway, phosphorylation, protease, sh3-binding, transmembrane, zinc, zymogen |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Membrane; Single-pass type I membrane protein: P78536 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 29652.95 |
構造登録者 | |
主引用文献 | Bandarage, U.K.,Wang, T.,Come, J.H.,Perola, E.,Wei, Y.,Rao, B.G. Novel thiol-based TACE inhibitors. Part 2: Rational design, synthesis, and SAR of thiol-containing aryl sulfones. Bioorg.Med.Chem.Lett., 18:44-48, 2008 Cited by PubMed: 18054488DOI: 10.1016/j.bmcl.2007.11.014 主引用文献が同じPDBエントリー |
実験手法 |
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