3B92

Novel thio-based TACE inhibitors Part 2: Rational design, synthesis and SAR of thiol-contaning aryl sufones

3B92 の概要

• エントリーDOI: 10.2210/pdb3b92/pdb
• 分子名称: ADAM 17, ZINC ION, 3-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}propane-1-thiol, ... (4 entities in total)
• 機能のキーワード: tnf-alpha converting enzyme, aryl-sulfonamide, tace inhibitors, alternative splicing, cleavage on pair of basic residues, glycoprotein, hydrolase, membrane, metal-binding, metalloprotease, notch signaling pathway, phosphorylation, protease, sh3-binding, transmembrane, zinc, zymogen
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P78536
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29652.95

構造登録者

Wei, Y. (登録日: 2007-11-02, 公開日: 2007-12-18, 最終更新日: 2023-08-30)

• 主引用文献: Bandarage, U.K.,Wang, T.,Come, J.H.,Perola, E.,Wei, Y.,Rao, B.G.; Novel thiol-based TACE inhibitors. Part 2: Rational design, synthesis, and SAR of thiol-containing aryl sulfones.; Bioorg.Med.Chem.Lett., 18:44-48, 2008; PubMed: 18054488; DOI: 10.1016/j.bmcl.2007.11.014

実験手法