3B8R

Crystal structure of the VEGFR2 kinase domain in complex with a naphthamide inhibitor

3B8R の概要

• エントリーDOI: 10.2210/pdb3b8r/pdb
• 関連するPDBエントリー: 3B8Q
• 分子名称: Vascular endothelial growth factor receptor 2, 1,2-ETHANEDIOL, N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide, ... (4 entities in total)
• 機能のキーワード: receptor tyrosine kinase, angiogenesis, atp-binding, developmental protein, differentiation, glycoprotein, host-virus interaction, immunoglobulin domain, membrane, nucleotide-binding, phosphorylation, polymorphism, transferase, transmembrane, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 73460.15

構造登録者

Whittington, D.A.,Long, A.M.,Gu, Y.,Zhao, H. (登録日: 2007-11-01, 公開日: 2008-04-01, 最終更新日: 2023-11-15)

• 主引用文献: Weiss, M.M.,Harmange, J.C.,Polverino, A.J.,Bauer, D.,Berry, L.,Berry, V.,Borg, G.,Bready, J.,Chen, D.,Choquette, D.,Coxon, A.,DeMelfi, T.,Doerr, N.,Estrada, J.,Flynn, J.,Graceffa, R.F.,Harriman, S.P.,Kaufman, S.,La, D.S.,Long, A.,Neervannan, S.,Patel, V.F.,Potashman, M.,Regal, K.,Roveto, P.M.,Schrag, M.L.,Starnes, C.,Tasker, A.,Teffera, Y.,Whittington, D.A.,Zanon, R.; Evaluation of a Series of Naphthamides as Potent, Orally Active Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitors; J.Med.Chem., 51:1668-1680, 2008; PubMed: 18324759; DOI: 10.1021/jm701098w

実験手法

X-RAY DIFFRACTION (2.7 Å)