3B6Z
Lovastatin polyketide enoyl reductase (LovC) complexed with 2'-phosphoadenosyl isomer of crotonoyl-CoA
Summary for 3B6Z
Entry DOI | 10.2210/pdb3b6z/pdb |
Related | 3B70 |
Descriptor | Enoyl reductase, S-{(9R,13R,15S)-17-[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)tetrahydrofuran-2-yl]-9,13,15-trihydroxy-10,10-dimethyl-13,15-dioxido-4,8-dioxo-12,14,16-trioxa-3,7-diaza-13,15-diphosphaheptadec-1-yl}(2E)-but-2-enethioate, GLYCEROL, ... (4 entities in total) |
Functional Keywords | medium-chain reductase, rossmann fold, nadp-binding, oxidoreductase |
Biological source | Aspergillus terreus |
Total number of polymer chains | 1 |
Total formula weight | 41550.59 |
Authors | Ames, B.D.,Smith, P.T.,Ma, S.M.,Wong, E.W.,Xie, X.,Vederas, J.C.,Tang, Y.,Tsai, S.-C. (deposition date: 2007-10-29, release date: 2008-09-16, Last modification date: 2024-02-21) |
Primary citation | Ames, B.D.,Nguyen, C.,Bruegger, J.,Smith, P.,Xu, W.,Ma, S.,Wong, E.,Wong, S.,Xie, X.,Li, J.W.,Vederas, J.C.,Tang, Y.,Tsai, S.C. Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis. Proc.Natl.Acad.Sci.USA, 109:11144-11149, 2012 Cited by PubMed: 22733743DOI: 10.1073/pnas.1113029109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.88 Å) |
Structure validation
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