3B3N
Structure of neuronal NOS heme domain in complex with a inhibitor (+-)-N1-{cis-4'-[(6"-aminopyridin-2"-yl)methyl]pyrrolidin-3'-yl}ethane-1,2-diamine
Summary for 3B3N
Entry DOI | 10.2210/pdb3b3n/pdb |
Related | 3B3M 3B3O 3B3P |
Descriptor | Nitric-oxide synthase, ACETATE ION, ZINC ION, ... (7 entities in total) |
Functional Keywords | nitric oxide synthase, heme enzyme, inhibitor, alternative splicing, calmodulin-binding, cell projection, fad, fmn, iron, membrane, metal-binding, nadp, oxidoreductase |
Biological source | Rattus norvegicus (Rat) |
Cellular location | Cell membrane, sarcolemma; Peripheral membrane protein (By similarity): P29476 |
Total number of polymer chains | 2 |
Total formula weight | 99994.68 |
Authors | Igarashi, J.,Li, H.,Poulos, T.L. (deposition date: 2007-10-22, release date: 2008-07-15, Last modification date: 2024-02-21) |
Primary citation | Ji, H.,Stanton, B.Z.,Igarashi, J.,Li, H.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Minimal pharmacophoric elements and fragment hopping, an approach directed at molecular diversity and isozyme selectivity. Design of selective neuronal nitric oxide synthase inhibitors. J.Am.Chem.Soc., 130:3900-3914, 2008 Cited by PubMed: 18321097DOI: 10.1021/ja0772041 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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