3B3N
Structure of neuronal NOS heme domain in complex with a inhibitor (+-)-N1-{cis-4'-[(6"-aminopyridin-2"-yl)methyl]pyrrolidin-3'-yl}ethane-1,2-diamine
3B3N の概要
エントリーDOI | 10.2210/pdb3b3n/pdb |
関連するPDBエントリー | 3B3M 3B3O 3B3P |
分子名称 | Nitric-oxide synthase, ACETATE ION, ZINC ION, ... (7 entities in total) |
機能のキーワード | nitric oxide synthase, heme enzyme, inhibitor, alternative splicing, calmodulin-binding, cell projection, fad, fmn, iron, membrane, metal-binding, nadp, oxidoreductase |
由来する生物種 | Rattus norvegicus (Rat) |
細胞内の位置 | Cell membrane, sarcolemma; Peripheral membrane protein (By similarity): P29476 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 99994.68 |
構造登録者 | |
主引用文献 | Ji, H.,Stanton, B.Z.,Igarashi, J.,Li, H.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Minimal pharmacophoric elements and fragment hopping, an approach directed at molecular diversity and isozyme selectivity. Design of selective neuronal nitric oxide synthase inhibitors. J.Am.Chem.Soc., 130:3900-3914, 2008 Cited by PubMed: 18321097DOI: 10.1021/ja0772041 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.98 Å) |
構造検証レポート
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