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3B3M

Structure of neuronal NOS heme domain in complex with a inhibitor (+-)-3-{cis-4'-[(6"-aminopyridin-2"-yl)methyl]pyrrolidin-3'-ylamino}propan-1-ol

Summary for 3B3M
Entry DOI10.2210/pdb3b3m/pdb
Related3B3N 3B3O 3B3P
DescriptorNitric-oxide synthase, ACETATE ION, ZINC ION, ... (7 entities in total)
Functional Keywordsnitric oxide synthase, heme enzyme, inhibitor, alternative splicing, calmodulin-binding, cell projection, fad, fmn, iron, membrane, metal-binding, nadp, oxidoreductase
Biological sourceRattus norvegicus (Rat)
Cellular locationCell membrane, sarcolemma; Peripheral membrane protein (By similarity): P29476
Total number of polymer chains2
Total formula weight100024.70
Authors
Igarashi, J.,Li, H.,Poulos, T.L. (deposition date: 2007-10-22, release date: 2008-07-15, Last modification date: 2024-02-21)
Primary citationJi, H.,Stanton, B.Z.,Igarashi, J.,Li, H.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B.
Minimal pharmacophoric elements and fragment hopping, an approach directed at molecular diversity and isozyme selectivity. Design of selective neuronal nitric oxide synthase inhibitors.
J.Am.Chem.Soc., 130:3900-3914, 2008
Cited by
PubMed: 18321097
DOI: 10.1021/ja0772041
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

217705

数据于2024-03-27公开中

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