3B3M

Structure of neuronal NOS heme domain in complex with a inhibitor (+-)-3-{cis-4'-[(6"-aminopyridin-2"-yl)methyl]pyrrolidin-3'-ylamino}propan-1-ol

3B3M の概要

• エントリーDOI: 10.2210/pdb3b3m/pdb
• 関連するPDBエントリー: 3B3N 3B3O 3B3P
• 分子名称: Nitric-oxide synthase, ACETATE ION, ZINC ION, ... (7 entities in total)
• 機能のキーワード: nitric oxide synthase, heme enzyme, inhibitor, alternative splicing, calmodulin-binding, cell projection, fad, fmn, iron, membrane, metal-binding, nadp, oxidoreductase
• 由来する生物種: Rattus norvegicus (Rat)
• 細胞内の位置: Cell membrane, sarcolemma; Peripheral membrane protein (By similarity): P29476
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100024.70

構造登録者

Igarashi, J.,Li, H.,Poulos, T.L. (登録日: 2007-10-22, 公開日: 2008-07-15, 最終更新日: 2024-02-21)

• 主引用文献: Ji, H.,Stanton, B.Z.,Igarashi, J.,Li, H.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B.; Minimal pharmacophoric elements and fragment hopping, an approach directed at molecular diversity and isozyme selectivity. Design of selective neuronal nitric oxide synthase inhibitors.; J.Am.Chem.Soc., 130:3900-3914, 2008; PubMed: 18321097; DOI: 10.1021/ja0772041

実験手法

X-RAY DIFFRACTION (1.95 Å)