3AW0
Structure of SARS 3CL protease with peptidic aldehyde inhibitor
Summary for 3AW0
Entry DOI | 10.2210/pdb3aw0/pdb |
Related | 3ATW 3AVZ 3AW1 |
Related PRD ID | PRD_001000 |
Descriptor | 3C-Like Proteinase, peptide ACE-SER-ALA-VAL-LEU-HIS-H (3 entities in total) |
Functional Keywords | hydrolase proteinase converting, designed inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | SARS coronavirus (SARS-CoV) More |
Cellular location | Non-structural protein 3: Host membrane ; Multi-pass membrane protein . Non-structural protein 4: Host membrane ; Multi-pass membrane protein . Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region : P0C6U8 |
Total number of polymer chains | 2 |
Total formula weight | 34369.25 |
Authors | Akaji, K.,Konno, H.,Mitsui, H.,Teruya, K.,Hattori, Y.,Ozaki, T.,Kusunoki, M.,Sanjho, A. (deposition date: 2011-03-09, release date: 2011-12-14, Last modification date: 2023-11-15) |
Primary citation | Akaji, K.,Konno, H.,Mitsui, H.,Teruya, K.,Shimamoto, Y.,Hattori, Y.,Ozaki, T.,Kusunoki, M.,Sanjoh, A. Structure-Based Design, Synthesis, and Evaluation of Peptide-Mimetic SARS 3CL Protease Inhibitors. J.Med.Chem., 54:7962-7973, 2011 Cited by PubMed: 22014094DOI: 10.1021/jm200870n PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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