3AVI

Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site

3AVI の概要

• エントリーDOI: 10.2210/pdb3avi/pdb
• 関連するPDBエントリー: 3AV9 3AVA 3AVB 3AVC 3AVF 3AVG 3AVH 3AVJ 3AVK 3AVL 3AVM 3AVN
• 関連するBIRD辞書のPRD_ID: PRD_000821
• 分子名称: Integrase, LEDGF peptide, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: protein-protein interactions, hiv, recombination-inhibitor complex, recombination/inhibitor
• 由来する生物種: Human immunodeficiency virus type 1 (HIV-1); 詳細
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P12497
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 43005.63

構造登録者

Peat, T.S.,Deadman, J.J.,Newman, J.,Rhodes, D.I. (登録日: 2011-03-05, 公開日: 2012-02-15, 最終更新日: 2013-06-19)

• 主引用文献: Rhodes, D.I.,Peat, T.S.,Vandegraaff, N.,Jeevarajah, D.,Newman, J.,Martyn, J.,Coates, J.A.,Ede, N.J.,Rea, P.,Deadman, J.J.; Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site.; Chembiochem, 12:2311-2315, 2011; PubMed: 21850718; DOI: 10.1002/cbic.201100350

実験手法

X-RAY DIFFRACTION (1.7 Å)